{"id":32262,"date":"2026-09-04T14:21:13","date_gmt":"2026-09-04T12:21:13","guid":{"rendered":"https:\/\/mederinutricion.com\/?p=32262"},"modified":"2026-09-04T15:00:37","modified_gmt":"2026-09-04T13:00:37","slug":"caprylic-acid-an-ally-in-the-keto-diet-and-overall-health","status":"publish","type":"post","link":"https:\/\/mederinutricion.com\/en\/caprylic-acid-an-ally-in-the-keto-diet-and-overall-health\/","title":{"rendered":"CAPRYLIC ACID: AN ALLY IN THE KETO DIET AND OVERALL HEALTH"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221; css_params=&#8221;&#8221;]Dr. Nuria Roda \/ Alberto Tejero<\/p>\n<p>Among current diets, the keto or ketogenic diet aims to achieve a state of ketosis in the body by consuming a higher amount of lipids than carbohydrates. Caprylic acid is a fatty acid that plays an important role in body functions at the metabolic, cardiovascular, and immune levels; anyone, regardless of their diet style, can benefit from its use.<\/p>\n<p>In today&#8217;s society, where there are many excesses in our diet, people look for diets or lifestyles to improve health or achieve physical or athletic goals. Among current diets is the keto or ketogenic diet, which consists of following a diet low in carbohydrates but high in fats, seeking to achieve a state of ketosis in which the body uses fat for energy instead of glucose, which would be the preference. In this case, energy for the brain and the rest of the body is obtained from a fat derivative: ketone bodies. These compounds, and the ketogenic diet in general, are associated with benefits such as weight control, improved insulin sensitivity, and better concentration.<\/p>\n<p>Within this diet, the consumption of medium-chain triglycerides (MCTs), especially caprylic acid or C8 (named for the number of carbons in its chemical structure), plays an important role. Because C8 has a simple structure, it is metabolized very quickly in the liver and converted almost immediately into ketone bodies, making it an efficient and stable energy source. Unlike other fats, it does not require complex digestive processes or prior storage, helping to achieve and maintain ketosis more easily. Being more water-soluble, it is not incorporated into chylomicrons and is generally accepted not to participate directly in lipogenesis. Below are more of this fatty acid&#8217;s health benefits:<\/p>\n<ul>\n<li><strong>Antifungal and Antimicrobial Action:<\/strong> C8 has demonstrated notable antimicrobial and antifungal activity in various <em>in vitro<\/em> studies and animal models when used in food applications. Particularly against <em>Candida albicans<\/em>, this medium-chain fatty acid inhibits biofilm formation, reduces cell adhesion, and blocks the transition from yeast to hyphae, a key process in fungal virulence. Against bacteria, it has shown bactericidal effects through direct damage to the cell membrane. These findings support its potential as an alternative or complement to conventional antimicrobials for controlling both fungal and bacterial infections, although human clinical trials are required to confirm its efficacy and safety.<\/li>\n<li><strong>Cardiovascular and Inflammatory Improvement:<\/strong> C8 has shown favorable effects on lipid metabolism and the inflammatory response in experimental models. In mice fed ketogenic diets, supplementation with this fatty acid significantly reduced total cholesterol and low-density lipoprotein (LDL) levels while improving the HDL\/LDL ratio, a critical marker of cardiovascular protection. At the molecular level, it was observed to promote the expression of the ABCA1 transporter, involved in cellular cholesterol efflux, and activate the JAK2\/STAT3 signaling pathway related to anti-inflammatory effects. Likewise, in cellular studies with macrophages exposed to lipopolysaccharides, it reduced the production of pro-inflammatory cytokines such as TNF-\u03b1 and IL-6, in addition to inhibiting the activation of NF-\u03baB, a central regulator of inflammation. All of this suggests that C8 not only improves lipid profiles but also helps attenuate systemic inflammation\u2014two processes closely linked to the development of atherosclerosis and metabolic diseases.<\/li>\n<li><strong>Modulation of Appetite-Related Hormones:<\/strong> C8 performs various actions on metabolism. While its role in energy production has already been discussed, it also plays a unique role in appetite regulation through its participation in activating ghrelin, the &#8220;hunger hormone&#8221;. For ghrelin to be biologically active, it needs to be acylated by the enzyme ghrelin O-acyltransferase (GOAT). The main substrate used by this enzyme is precisely caprylic acid. Without the binding of a caprylic group, ghrelin remains in its unacylated form and does not exert orexigenic (appetite-stimulating) effects. Conversely, ghrelin acylated thanks to C8 is what stimulates appetite, increases caloric intake, and modulates energy metabolism by acting on hypothalamic receptors. Beyond appetite regulation, this function also connects to body weight control, glycemic homeostasis, and growth hormone secretion\u2014processes in which ghrelin is involved. In people with pathological weight loss (cancer, chronic diseases, anorexia nervosa, advanced age-associated cachexia), activated ghrelin would help increase appetite and caloric intake. This can also promote protein synthesis and muscle mass preservation in catabolic conditions. It would also be useful in gastroparesis\u2014disorders involving delayed gastric emptying\u2014to stimulate gastric and intestinal motility.<\/li>\n<li><strong>Effect on Blood Pressure:<\/strong> Some experimental studies have reported that caprylic acid can directly influence hemodynamic parameters and cardiac function. In a guinea pig model, C8 administration was observed to produce an increase in cardiac output and a decrease in blood pressure and peripheral vascular resistance. Furthermore, it showed a positive inotropic effect, meaning it increased the heart&#8217;s force of contraction. These effects were partially inhibited by indomethacin, suggesting the involvement of prostaglandins in its mechanism of action. This finding points to its ability to modulate cardiovascular function not only through lipid metabolism and inflammation but also through vasoactive pathways. Therefore, although more research is needed, it could be beneficial for controlling blood pressure or cardiac output.<\/li>\n<\/ul>\n<p>In conclusion, caprylic acid plays a key role in essential bodily functions across metabolic, cardiovascular, and immune levels. As demonstrated, anyone\u2014regardless of their dietary style\u2014can benefit from its use.<\/p>\n<p><strong>Bibliographical References:<\/strong><\/p>\n<ol>\n<li>S\u00e1yago-Ayerdi, S. G., Vaquero, M. P., Schultz-Moreira, A., Bastida, S., &amp; S\u00e1nchez-Muniz, F. J. (2008). Utility and controversies of medium-chain fatty acid consumption on lipoprotein metabolism and obesity. <em>Nutrici\u00f3n Hospitalaria<\/em>, 23(3), 191-202.<\/li>\n<li>Jadhav, A., Mortale, S., Halbandge, S., Jangid, P., Patil, R., Gade, W., Kharat, K., &amp; Karuppayil, S. M. (2017). The Dietary Food Components Capric Acid and Caprylic Acid Inhibit Virulence Factors in Candida albicans Through Multitargeting. <em>Journal of Medicinal Food<\/em>, 20(11), 1083\u20131090. <a href=\"https:\/\/www.google.com\/search?q=https:\/\/doi.org\/10.1089\/jmf.2017.3971\">https:\/\/doi.org\/10.1089\/jmf.2017.3971<\/a><\/li>\n<li>Valipe, S. R., Nadeau, J. A., Annamali, T., Venkitanarayanan, K., &amp; Hoagland, T. (2011). In vitro antimicrobial properties of caprylic acid, monocaprylin, and sodium caprylate against Dermatophilus congolensis. <em>American Journal of Veterinary Research<\/em>, 72(3), 331-335.<\/li>\n<li>Huang, C. B., Alimova, Y., Myers, T. M., &amp; Ebersole, J. L. (2011). Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. <em>Archives of Oral Biology<\/em>, 56(7), 650\u2013654. <a href=\"https:\/\/www.google.com\/search?q=https:\/\/doi.org\/10.1016\/j.archoralbio.2011.01.011\">https:\/\/doi.org\/10.1016\/j.archoralbio.2011.01.011<\/a><\/li>\n<li>Zhang, X. S., Zhang, P., Liu, Y. H., Xu, Q., Zhang, Y., Li, H. Z., Liu, L., Liu, Y. M., Yang, X. Y., &amp; Xue, C. Y. (2022). Caprylic Acid Improves Lipid Metabolism, Suppresses the Inflammatory Response and Activates the ABCA1\/p-JAK2\/p-STAT3 Signaling Pathway in C57BL\/6J Mice and RAW264.7 Cells. <em>Biomedical and Environmental Sciences: BES<\/em>, 35(2), 95\u2013106. <a href=\"https:\/\/www.google.com\/search?q=https:\/\/doi.org\/10.3967\/bes2022.014\">https:\/\/doi.org\/10.3967\/bes2022.014<\/a><\/li>\n<li>Lemari\u00e9, F., Beauchamp, E., Drouin, G., Legrand, P., &amp; Rioux, V. (2018). Dietary caprylic acid and ghrelin O-acyltransferase activity to modulate octanoylated ghrelin functions: What is new in this nutritional field?. <em>Prostaglandins, Leukotrienes, and Essential Fatty Acids<\/em>, 135, 121\u2013127. <a href=\"https:\/\/www.google.com\/search?q=https:\/\/doi.org\/10.1016\/j.plefa.2018.07.009\">https:\/\/doi.org\/10.1016\/j.plefa.2018.07.009<\/a><\/li>\n<li>Kristev, A., Mitkov, D., Lukanov, Y., &amp; Chapkynov, P. (1989). The effect of octanoic fatty acid on the cardiovascular system of the guinea pig. <em>Cor et Vasa<\/em>, 31(4), 321\u2013327.<\/li>\n<\/ol>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221; css_params=&#8221;&#8221;]Dr. Nuria Roda \/ Alberto Tejero Among current diets, the keto or ketogenic diet aims to achieve a state of ketosis in the body by consuming a higher amount of lipids than carbohydrates. Caprylic acid is a fatty acid that plays an important role in body functions at the metabolic, cardiovascular, and immune [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":32261,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[186],"tags":[],"class_list":["post-32262","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-integrative-nutrition"],"featured_image_src":{"landsacpe":["https:\/\/mederinutricion.com\/wp-content\/uploads\/2026\/09\/MCT_blog_Mederi-1080x445.jpg",1080,445,true],"list":["https:\/\/mederinutricion.com\/wp-content\/uploads\/2026\/09\/MCT_blog_Mederi-463x348.jpg",463,348,true],"medium":["https:\/\/mederinutricion.com\/wp-content\/uploads\/2026\/09\/MCT_blog_Mederi-300x167.jpg",300,167,true],"full":["https:\/\/mederinutricion.com\/wp-content\/uploads\/2026\/09\/MCT_blog_Mederi.jpg",1080,600,false]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CAPRYLIC ACID: AN ALLY IN THE KETO DIET AND OVERALL HEALTH - M\u00e9deri<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mederinutricion.com\/en\/caprylic-acid-an-ally-in-the-keto-diet-and-overall-health\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CAPRYLIC ACID: AN ALLY IN THE KETO DIET AND OVERALL HEALTH - M\u00e9deri\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text css=&#8221;&#8221; css_params=&#8221;&#8221;]Dr. Nuria Roda \/ Alberto Tejero Among current diets, the keto or ketogenic diet aims to achieve a state of ketosis in the body by consuming a higher amount of lipids than carbohydrates. 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